Nachhaltiges Bauen und nachhaltige Flächennutzung

NACHHALTIGES BAUEN UND NACHHALTIGE FLÄCHENNUTZUNG Nachhaltiges Bauen und nachhaltige Flächennutzung / Scharp, Michael (Rights reserved) ( -

Energiedienstleistungen zur Unterstützung von Endverbrauchern

Um die Klimaschutzziele zu erreichen, muss beim Wohnen viel Energie eingespart werden. Doch wie viel Energie kann man durch Verhaltensänderungen einsparen? Ein EU-Projekt bietet mit Energiedienstleistungen Unterstützung für Endverbraucher

BewareE-Handbuch: Energiedienstleistungen für Mieter und die Wohnungswirtschaft

BEWAREE-HANDBUCH: ENERGIEDIENSTLEISTUNGEN FÜR MIETER UND DIE WOHNUNGSWIRTSCHAFT BewareE-Handbuch: Energiedienstleistungen für Mieter und die Wohnungswirtschaft / Scharp, Michael (Rights reserved) ( -

Instrument zur Früherkennung umweltpolitischer Chancen und Risiken

Um negative ökologische Effekte zu vermeiden, wird eine frühzeitige Abschätzung von zukünftigen Auswirkungen und Trends immer wichtiger. Mit einem neuen Instrument zur Früherkennung können Chancen und Risiken für die Umweltpolitik identifiziert werden

Learning from sustainability pioneers. The Korn-Scout project

Das Projekt Korn-Scout entwickelt betriebliche Lehr-Lern-Materialien für Auszubildende in Korn-handhabenden Berufen. Ziel ist die Vermittlung von Nachhaltigkeitskompetenzen insbesondere zur Kommunikation mit den Akteuren der Wertschöpfungskette, um Auszubildende zu Change Agents ihrer Branche zu machen. Entscheidende Impulse kommen von den Praxispartnern und Praxispartnerinnen im Projekt – erfolgreichen Nachhaltigkeitspionieren. Diese stellen in „korn – Die Zeitschrift für Azubis“ ihre Erfahrungen und ihre Beweggründe für nachhaltiges Handeln vor. (DIPF/Orig.)The Korn-Scout project develops company-based teaching-learning materials for trainees in grain-handling professions. The aim is to impart sustainability competencies, especially for communication with the actors in the value chain, to make trainees change agents in their sector. Decisive impulses come from the practice partners in the project—successful sustainability pioneers. In “korn – Die Zeitschrift für Azubis” (corn – Magazine for Apprentices) they present their experiences and their motives for sustainable action. (DIPF/Orig.

Report from IPITA-TTS opinion leaders meeting on the future of β-cell replacement

Peer reviewe

Enumeration of islets by nuclei counting and light microscopic analysis

Author Manuscript 2011 May 1.Islet enumeration in impure preparations by conventional dithizone staining and visual counting is inaccurate and operator dependent. We examined nuclei counting for measuring the total number of cells in islet preparations, and we combined it with morphological analysis by light microscopy (LM) for estimating the volume fraction of islets in impure preparations. Cells and islets were disrupted with lysis solution and shear, and accuracy of counting successively diluted nuclei suspensions was verified with (1) visual counting in a hemocytometer after staining with crystal violet, and automatic counting by (2) aperture electrical resistance measurement and (3) flow cytometer measurement after staining with 7-aminoactinomycin-D. DNA content averaged 6.5 and 6.9 pg of DNA per cell for rat and human islets, respectively, in agreement with literature estimates. With pure rat islet preparations, precision improved with increasing counts, and samples with about greater than or equal to 160 islets provided a coefficient of variation of about 6%. Aliquots of human islet preparations were processed for LM analysis by stereological point counting. Total nuclei counts and islet volume fraction from LM analysis were combined to obtain the number of islet equivalents (IEs). Total number of IE by the standard method of dithizone staining/manual counting was overestimated by about 90% compared with LM/nuclei counting for 12 freshly isolated human islet research preparations. Nuclei counting combined with islet volume fraction measurements from LM is a novel method for achieving accurate islet enumeration.National Institutes of Health (U.S.) (Grant NCRR ICR U4Z 16606)National Institutes of Health (U.S.) (Grant R01-DK063108-01A1)National Institutes of Health (U.S.) (Grant NCRR ICR U42 RR0023244-01)Joslin Diabetes and Endocrinology Research Center (Grant DK36836)Diabetes Research & Wellness FoundationJuvenile Diabetes Research Foundation International (Islet Transplantation, Harvard Medical School

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate. We evaluated the materials in vivo and identified three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates. The distribution of the triazole modification creates a unique hydrogel surface that inhibits recognition by macrophages and fibrous deposition. In addition to the utility of the compounds reported here, our approach may enable the discovery of other materials that mitigate the foreign body response.Leona M. and Harry B. Helmsley Charitable Trust (3-SRA-2014-285-M-R)United States. National Institutes of Health (EB000244)United States. National Institutes of Health (EB000351)United States. National Institutes of Health (DE013023)United States. National Institutes of Health (CA151884)United States. National Institutes of Health (P41EB015871-27)National Cancer Institute (U.S.) (P30-CA14051